منابع مشابه
Cyclic neutropenia in grey collie dogs.
By JOHN E. LUND, GEoRGE A. PADCEYF AND RIChARD L. Orr C YCLIC NEUTROPENIA is a rare hematologic disorder characterized by the chronic, cyclical recurrence of severe neutropenia which has previously 1)een described only in humans. The neutropenia recurs approximately every 21 days and lasts from 3 to 10 days. The clinical manifestations of the disease are observed during the neutropenic phase of...
متن کاملCyclic hematopoiesis: the mechanism of cyclic neutropenia in grey collie dogs.
Two grey collie dogs had regular cyclic fluctuations in the number of all formed elements of the blood. The period lengths for all elements for an individual dog were the same, but the pattern of fluctuation for each element was distinctive. Normal dogs lacked periodic fluctuations.The patterns of day-to-day variation in the normal dogs counts were consistent with a first-order autoregressive p...
متن کاملStudies of neutrophil production and turnover in grey collie dogs with cyclic neutropenia.
12 grey collie dogs had cyclic neutropenia with the neutropenia recurring at 11.8+/-0.1-day intervals. The recovery from neutropenia was accompanied by a single wave of myeloid proliferation, an increase in marrow myeloid-labeling indices, and an increase in serum muramidase levels. After recovery from neutropenia during the period when blood neutrophils (PMN) were normal or increased, marrow m...
متن کاملCyclic hematopoiesis in grey collie dogs: a stem-cell problem.
Studies were made to ascertain the possipetition for a limiting number of pluripoble basis of cyclic hematopoiesis in the tential stem cells with the alternating grey collie. The results of 3H-thymidine competitive pressure provided by activaand “Fe labeling in conjunction with other tion and deactivation of a neutrophil feedmarrow parameters and peripheral counts back circuit from periphery to...
متن کاملCyclic hematopoiesis. Effects of endotoxin on colony-forming cells and colony-stimulating activity in grey collie dogs.
Cyclic changes in blood neutrophil counts of grey collie dogs with cyclic hematopoiesis can be eliminated by daily endotoxin injections. Studies were performed to determine the mechanism whereby endotoxin alters this disease. Bone marrow granulocyte-macrophage progenitor cells (colony-forming cells [CFUc]) showed cyclic variation in the untreated grey collie, which was eliminated by chronic end...
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ژورنال
عنوان ژورنال: Blood
سال: 1967
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v29.4.452.452